碱性成纤维细胞生长因子和表皮生长因子可促进新生大鼠原代培养小脑神经元的存活。
Basic fibroblast growth factor and epidermal growth factor promote survival of primary cultured cerebellar neurons from neonatal rats.
作者信息
Abe K, Takayanagi M, Saito H
机构信息
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
Jpn J Pharmacol. 1991 May;56(1):113-6. doi: 10.1254/jjp.56.113.
Neurotrophic effects of CS23, a mutein of human basic fibroblast growth factor (bFGF), and recombinant human epidermal growth factor (hEGF) were compared in dissociated cerebellar cultures from embryonic (E20) and early postnatal (P0-5) rats. Both CS23 and hEGF promoted the survival of cerebellar neurons without distinction of ages of animals used. The maximum effects of CS23 were always larger than those of hEGF. These results suggest that both bFGF and EGF also function as neurotrophic factors in postnatal cerebellum.
在来自胚胎期（E20）和出生后早期（P0 - 5）大鼠的解离小脑培养物中，比较了人碱性成纤维细胞生长因子（bFGF）的突变蛋白CS23和重组人表皮生长因子（hEGF）的神经营养作用。CS23和hEGF均能促进小脑神经元的存活，且不受所用动物年龄的影响。CS23的最大作用总是大于hEGF。这些结果表明，bFGF和EGF在出生后的小脑中也作为神经营养因子发挥作用。
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