Leite Mariana Ferreira, Nicolau José
Centro de Pesquisa em Biologia Oral, Faculdade de Odontologia da Universidade de São Paulo, Av Lineu Prestes, 2227, São Paulo, SP, Brazil, CEP 05508-000.
Biol Trace Elem Res. 2009 Feb;127(2):154-63. doi: 10.1007/s12011-008-8233-5. Epub 2008 Sep 20.
Several studies have shown the antidiabetic properties of sodium tungstate. In this study, we evaluated some biochemical parameters of the parotid salivary gland of streptozotocin-induced diabetic rats treated with sodium tungstate solution (2 mg/ml). The studied groups were: untreated control (UC), treated control (TC), untreated diabetic (UD), and treated diabetic (TD). After 2 and 6 weeks of treatment, parotid gland was removed and total protein and sialic acid (free and total) concentration and amylase and peroxidase activities were determined. Data were compared by variance analysis and Tukey test (p < 0.05). The sodium tungstate treatment modestly decreased the glycemia of streptozotocin-induced diabetic rats. At week 2 of the study, parotid gland of diabetic rats presented a reduction of total protein concentration (55%) and an increase of amylase (120%) and peroxidase (160%) activities, free (150%) and total (170%) sialic acid concentration. No alteration in the evaluated parameters at week 6 of the study was observed. Sodium tungstate presented no significant effect in parotid gland. Our results suggest that diabetes causes initial modification in biochemical composition of parotid. However, this gland showed a recovery capacity after 6 week of the experimental time. Sodium tungstate has no effect in peripheral tissues, such as salivary glands.
多项研究已表明钨酸钠具有抗糖尿病特性。在本研究中，我们评估了用钨酸钠溶液（2毫克/毫升）处理的链脲佐菌素诱导的糖尿病大鼠腮腺的一些生化参数。研究组包括：未处理对照组（UC）、处理对照组（TC）、未处理糖尿病组（UD）和处理糖尿病组（TD）。治疗2周和6周后，切除腮腺并测定总蛋白、唾液酸（游离和总含量）浓度以及淀粉酶和过氧化物酶活性。数据通过方差分析和Tukey检验进行比较（p<0.05）。钨酸钠治疗适度降低了链脲佐菌素诱导的糖尿病大鼠的血糖。在研究的第2周，糖尿病大鼠的腮腺总蛋白浓度降低（55%），淀粉酶（120%）和过氧化物酶（160%）活性、游离（150%）和总（170%）唾液酸浓度增加。在研究的第6周，未观察到评估参数有变化。钨酸钠对腮腺无显著影响。我们的结果表明，糖尿病会导致腮腺生化组成的初始改变。然而，在实验时间6周后，该腺体显示出恢复能力。钨酸钠对唾液腺等外周组织无作用。
