Gabuniia R I, Romanova L F, Pinkera A, Matiakin E G, Duditskaia T K
Med Radiol (Mosk). 1991;36(7):29-32.
Investigations using a radioimmunoassay in 92 patients with nodular goiter, thyroid adenoma and cancer have shown that changes in the levels of T4, T3 and TSH cannot be used in differential diagnosis of tumors. A high level of thyroglobulin (TG) in 70-75% of patients in the absence of antibodies to it and the presence of a "cold node" on a scan is suggestive of differentiated types of thyroid cancer. In these cases TG can serve as a tumor marker. A moderate level of Tg in 25-30% of cases against a background of a high level of antibodies to it does not permit its use as a tumor marker in such patients even in the postoperative period. High levels of TG and TSH despite the use of thyroid drugs in patients, operated on for differentiated types of thyroid cancer, may be suggestive of a possible manifestation of a recurrence or metastatic spreading.
对92例结节性甲状腺肿、甲状腺腺瘤和癌症患者进行的放射免疫分析研究表明，T4、T3和TSH水平的变化不能用于肿瘤的鉴别诊断。70%-75%的患者甲状腺球蛋白（TG）水平较高，且不存在针对它的抗体，同时扫描显示有“冷结节”，提示为分化型甲状腺癌。在这些情况下，TG可作为肿瘤标志物。25%-30%的病例中，在针对TG的抗体水平较高的背景下，TG水平中等，即使在术后阶段，也不允许将其用作此类患者的肿瘤标志物。对于接受过分化型甲状腺癌手术的患者，尽管使用了甲状腺药物，但TG和TSH水平较高，可能提示复发或转移扩散的可能表现。
