Kawaoi A, Okano T, Nemoto N, Shiina Y, Shikata T
Am J Pathol. 1982 Jul;108(1):39-49.
In 97 nontoxic thyroid tumors, detection of thyroxine(T4) and triiodothyronine(T3) was attempted by the immunoperoxidase method. T4 was demonstrated in 58 tumors (59.8%) and T3 in 76 (78.4%). The feasibility of biosynthesis of T4 and T3 by such tumors was thus established. In 65 of the tumors, we applied the immunostaining method to serial or semiserial sections to study the correlation among the localizations of thyroglobulin(Tg), T4, and T3. The localization of T4 agreed relatively well with that of Tg, and part of the Tg-positive structure frequently revealed simultaneous positive staining for T4. The localization of T3, however, did not always correspond with that of T4 or Tg. T4 and T3 with localizations identical to that of Tg may be considered to be bound to Tg, but the mode of existence of T3 without correspondence in localization to Tg remains unknown.
在97例非毒性甲状腺肿瘤中，尝试采用免疫过氧化物酶法检测甲状腺素（T4）和三碘甲状腺原氨酸（T3）。58例肿瘤（59.8%）检测到T4，76例（78.4%）检测到T3。由此确定了此类肿瘤生物合成T4和T3的可行性。在65例肿瘤中，我们对连续或半连续切片应用免疫染色法，以研究甲状腺球蛋白（Tg）、T4和T3定位之间的相关性。T4的定位与Tg的定位相对吻合，部分Tg阳性结构常显示T4同时呈阳性染色。然而，T3的定位并不总是与T4或Tg的定位一致。定位与Tg相同的T4和T3可能被认为与Tg结合，但定位与Tg不对应的T3的存在方式仍然未知。
