Moonen C T, Pekar J, de Vleeschouwer M H, van Gelderen P, van Zijl P C, DesPres D
In Vivo NMR Research Center, BEIP, NCRR, National Institutes of Health, Bethesda, Maryland 20892.
Magn Reson Med. 1991 Jun;19(2):327-32. doi: 10.1002/mrm.1910190223.
The occlusion of the middle cerebral artery in cat brain was used as an experimental stroke model to investigate the physical basis of the recently reported lowered diffusion constant of water in acute infarcted brain tissue (Moseley et al., Magn. Reson. Med. 14, 330, 1990). The original findings were confirmed in this study of 12 animals investigated with the diffusion-sensitized stimulated echo sequence. The following additional results were obtained: First, the onset of significant lowering of the diffusion constant in the stroke area varied significantly (up to 2.5 h depending on the animal). Second, the affected area is much more clearly outlined in diffusion-weighted images than in T2-weighted images, even in the period between 3 to 12 h following occlusion. Third, for diffusion times between 50 and 2000 ms. the diffusion constant of water is independent of diffusion time in healthy tissue, as well as in the stroke area. Fourth, the diffusion anisotropy is similar in healthy and in stroke area and remains similar regardless of the diffusion time used.
将猫脑大脑中动脉闭塞用作实验性中风模型，以研究近期报道的急性梗死脑组织中水的扩散常数降低的物理基础（莫斯利等人，《磁共振医学》14卷，第330页，1990年）。在这项对12只动物进行的研究中，使用扩散敏感的刺激回波序列证实了最初的发现。还获得了以下额外结果：第一，中风区域扩散常数显著降低的起始时间差异很大（取决于动物，最长可达2.5小时）。第二，即使在闭塞后3至12小时之间，扩散加权图像中受影响区域的轮廓也比T2加权图像中更清晰。第三，对于50至2000毫秒之间的扩散时间，健康组织以及中风区域中水的扩散常数与扩散时间无关。第四，健康区域和中风区域的扩散各向异性相似，并且无论使用何种扩散时间都保持相似。
