Jehl F, Kolbe R, Chrétien P, Rosembaum M, Monteil H
Faculté de Médecine, Institut de Bactériologie, Strasbourg.
Pathol Biol (Paris). 1991 May;39(5):511-4.
The gingival penetration of roxithromycin was evaluated at steady-state in twenty nine patients treated by 150 mg orally every 12 h during five days. Tissue specimen were sampled at 2 h (n = 6), 4 h (n = 6), 6 h (n = 5), 8 h (n = 6) and 12 h (n = 6) after the 10th administration. One blood sample was drawn at the same times. Serum and tissue concentrations of roxithromycin were measured by high performance liquid chromatography (HPLC). Serum peak level, measured at the 4th h, reached 6.60 +/- 1.15 micrograms/ml. The tissue peak concentration was 4.63 +/- 1.84 micrograms/g at the 8th h. Between the 4th and 10th hour after administration, the tissue concentrations are above 2 micrograms/g, i.e. above roxithromycin MIC 90 against most of the encountered pathogens in stomatologic infections.
在29例患者中评估了罗红霉素的牙龈渗透情况，这些患者连续五天每12小时口服150毫克罗红霉素，处于稳态。在第10次给药后的2小时（n = 6）、4小时（n = 6）、6小时（n = 5）、8小时（n = 6）和12小时（n = 6）采集组织样本。在相同时间采集一份血样。采用高效液相色谱法（HPLC）测定罗红霉素的血清和组织浓度。在第4小时测得的血清峰值水平达到6.60±1.15微克/毫升。在第8小时组织峰值浓度为4.63±1.84微克/克。给药后第4至10小时之间，组织浓度高于2微克/克，即高于罗红霉素对口腔感染中大多数常见病原体的MIC90。
