一种用于安乐死兽医药物塔纳克斯（Tanax）的液相色谱 - 串联质谱法的开发。
Development of a liquid chromatography-tandem mass spectrometry method for an euthanasic veterinarian drug: Tanax.
作者信息
Fidani M, Gamberini M C, Pasello E, Palazzoli F, Dimasi T, Montana M
机构信息
U.N.I.R.E. Lab. S.r.l., Via Gramsci 70, 20019 Settimo Milanese (MI), Italy.
出版信息
J Pharm Biomed Anal. 2008 Nov 4;48(3):902-8. doi: 10.1016/j.jpba.2008.07.024. Epub 2008 Aug 8.
A development of a rapid and sensitive LC-MS/MS method for the simultaneous detection of active ingredients of the euthanasic veterinarian drug Tanax mixture is described. The method proposed, with a retention time of few minutes (6 min) was developed for an equine serum sample with solid-phase extraction (S.P.E). This S.P.E. procedure has been revealed useful for the determination of very low concentrations of Tanax analytes (0.05-1 ng/ml). The method was validated in terms of specificity/selectivity, sensitivity, recovery and precision.
本文描述了一种用于同时检测安乐死兽医药物塔纳克斯混合物活性成分的快速灵敏液相色谱-串联质谱（LC-MS/MS）方法的开发。所提出的方法保留时间短（6分钟），是针对马血清样本采用固相萃取（S.P.E）开发的。该固相萃取程序已被证明对于测定极低浓度的塔纳克斯分析物（0.05 - 1 ng/ml）很有用。该方法在特异性/选择性、灵敏度、回收率和精密度方面进行了验证。
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