Octave Jean-Noël, Pierrot Nathalie
Laboratoire de Pharmacologie Expérimentale, Université catholique de Louvain, FARL 5410, Avenue Hippocrate 54 B-1200 Bruxelles.
Bull Acad Natl Med. 2008 Feb;192(2):323-31; discussion 331-2.
Alzheimer's disease is characterized by the presence of neurofibrillary tangles and senile plaque in the brain. Both disorders must be present in order to confirm a clinical diagnosis of Alzheimer's disease. Neurofibrillary tangles contain hyperphosphorylated microtubule-associated protein tau, while senile plaque contains a core of amyloidpeptide derived from its precursor. Phosphorylation of both amyloid precursor protein and tau represents a biochemical link between the two characteristic lesions of Alzheimer's disease.
阿尔茨海默病的特征是大脑中存在神经原纤维缠结和老年斑。必须同时存在这两种病变才能确诊阿尔茨海默病的临床诊断。神经原纤维缠结包含高度磷酸化的微管相关蛋白tau，而老年斑包含源自其前体的淀粉样肽核心。淀粉样前体蛋白和tau的磷酸化代表了阿尔茨海默病两种特征性病变之间的生化联系。
