El-Menyar Ayman, Amin Haitham, Rashdan Ibrahim, Souliman Kadhim, Deleu Dirk, Saadat Kamran, Al Mahmeed Wael, Bakir Sharif, Wasif Adel, Ben Brek Azan, Bazargani Nooshin, Singh Rajvir, Hatou Iman, Mahmoud Hisham, Al Suwaidi Jassim
Department of Cardiology and Cardiovascular Surgery, Medical Research Center Hamad Medical Corporation, Qatar.
Angiology. 2009 Jun-Jul;60(3):329-34. doi: 10.1177/0003319708321585. Epub 2008 Sep 26.
To assess the extent of atherothrombosis and the use of the ankle-brachial index (ABI) in populations from the Middle East, we conducted a multicenter study similar to AGATHA (a Global Atherothrombosis Assessment), AGATHA-ME, which included 1341 patients from 18 centers from 5 countries (United Arab Emirates, Kuwait, Qatar, Bahrain, and Oman). Patients were assigned to 2 groups: the with-disease and at-risk groups. Abnormal ABI (< or =0.9) was seen in 31.5% of at-risk patients and 28.2% of with-disease patients. Patients with peripheral arterial disease had the highest frequency of abnormal ABI (77.6%), with 97.8 negative predictive value. The AGATHA-ME study confirms that atherothrombosis disease often occurs at more than 1 site. The ABI is related to the risk factor profile and to the site and extent of atherothrombosis. Gender and diabetes mellitus are associated with the worst parameters.
为评估中东地区人群的动脉粥样硬化血栓形成情况以及踝臂指数（ABI）的应用，我们开展了一项类似于AGATHA（全球动脉粥样硬化血栓形成评估）的多中心研究——AGATHA-ME，该研究纳入了来自5个国家（阿联酋、科威特、卡塔尔、巴林和阿曼）18个中心的1341例患者。患者被分为两组：患病组和风险组。在风险组患者中，31.5%的患者ABI异常（≤0.9），在患病组患者中这一比例为28.2%。外周动脉疾病患者ABI异常的频率最高（77.6%），阴性预测值为97.8%。AGATHA-ME研究证实，动脉粥样硬化血栓形成疾病常发生于不止一个部位。ABI与危险因素谱以及动脉粥样硬化血栓形成的部位和范围相关。性别和糖尿病与最差的参数相关。
