Bor A S E, Rinkel G J E, Adami J, Koffijberg H, Ekbom A, Buskens E, Blomqvist P, Granath F
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands.
Brain. 2008 Oct;131(Pt 10):2662-5. doi: 10.1093/brain/awn187. Epub 2008 Sep 26.
Relatives of patients with aneurysmal subarachnoid haemorrhage (SAH) have an increased risk of this type of stroke. In a population-based study, we analysed individualized risks of SAH according to the number of affected first-degree relatives. We retrieved all patients diagnosed with SAH in 2001-05 from the Swedish Inpatient Register. For each of the 5,282 patients, we identified five controls (n = 26,402) through the nationwide Register of Total Population. Through the Multi-generation Register, we retrieved all first-degree relatives for patients and controls and checked whether these 130,373 relatives had been diagnosed with SAH. By means of conditional logistic regression, we calculated odds ratios with corresponding 95% confidence intervals (95% CI) for the risk of SAH according to the number of affected relatives, and to the gender, age and type of kinship of the patient and affected relative. The odds ratio of SAH for individuals with one affected first-degree relative was 2.15 (95% CI 1.77-2.59). For individuals with two affected first-degree relatives, the odds ratio was 51.0 (95% CI 8.56-1117). Gender, age and type of kinship did not influence the risk for individuals with one or more affected relatives. The risk of SAH is slightly increased in the cases with one, but strongly increased in cases with two or more affected first-degree relatives. The latter strongly increased risk corresponds to a considerable absolute life-time risk of SAH and underscores the need to consider screening for aneurysms in these individuals.
动脉瘤性蛛网膜下腔出血（SAH）患者的亲属发生这种类型中风的风险增加。在一项基于人群的研究中，我们根据受影响的一级亲属数量分析了SAH的个体风险。我们从瑞典住院患者登记处检索了2001 - 2005年期间所有被诊断为SAH的患者。对于这5282名患者中的每一位，我们通过全国总人口登记处确定了五名对照（n = 26402）。通过多代登记处，我们检索了患者和对照的所有一级亲属，并检查这些130373名亲属是否被诊断为SAH。通过条件逻辑回归，我们根据受影响亲属的数量以及患者和受影响亲属的性别、年龄和亲属关系类型，计算了SAH风险的比值比及其相应的95%置信区间（95%CI）。有一名受影响一级亲属的个体发生SAH的比值比为2.15（95%CI 1.77 - 2.59）。有两名受影响一级亲属的个体，比值比为51.0（95%CI 8.56 - 1117）。性别、年龄和亲属关系类型对有一名或多名受影响亲属的个体的风险没有影响。有一名受影响亲属的情况下，SAH风险略有增加，但有两名或更多受影响一级亲属的情况下，风险大幅增加。后者大幅增加的风险对应着相当大的SAH终生绝对风险，并强调了在这些个体中考虑进行动脉瘤筛查的必要性。
