Joshi Smita N, Das Soma, Thakar Madhuri, Sahasrabuddhe Vikrant, Kumar B Kishore, Callahan Marianne, Mauck Christine
National AIDS Research Institute, Pune, India.
J Low Genit Tract Dis. 2008 Oct;12(4):293-9. doi: 10.1097/LGT.0b013e31817efbbd.
We assessed colposcopically observed vascular changes occurring in the cervix in relation to cyclical hormonal variation in healthy women.
Thirty women with regular menstrual cycles and willing to remain sexually abstinent during a menstrual cycle were enrolled. Colposcopy was performed during the peak of the estrogen and progesterone levels.
The mean (+/-SD) diameter of the largest visible blood vessel differed significantly between the estrogenic phase (0.38 +/- 0.14 mm) as compared with the progestogenic phase (0.47 +/- 0.12 mm; p <.01). The blood vessels were more prominent and dense and had a well-defined outline during the progestogenic phase than the estrogenic phase; however, these differences were not statistically significant. There was borderline increase in the interleukin 8 level during the estrogenic phase.
Physiological changes of increased vascularity of the cervix observed colposcopically during the progestogenic phase are normal. If such changes do not correspond to the menstrual cycle phase in women using vaginal microbicides in early-phase clinical trials, presence of inflammatory markers should be evaluated. Elevated interleukin 8 during the estrogenic phase needs further evaluation.
我们评估了健康女性宫颈中与周期性激素变化相关的阴道镜观察到的血管变化。
招募了30名月经周期规律且愿意在一个月经周期内保持禁欲的女性。在雌激素和孕激素水平达到峰值时进行阴道镜检查。
可见最大血管的平均（±标准差）直径在雌激素期（0.38±0.14毫米）与孕激素期（0.47±0.12毫米；p<0.01）之间存在显著差异。与雌激素期相比，孕激素期血管更突出、更密集，轮廓更清晰；然而，这些差异无统计学意义。雌激素期白细胞介素8水平有临界升高。
在孕激素期阴道镜观察到的宫颈血管增多的生理变化是正常的。在早期临床试验中，使用阴道杀菌剂的女性若此类变化与月经周期阶段不符，应评估炎症标志物的存在情况。雌激素期白细胞介素8升高需进一步评估。
