Stefániková L, Freibergerová M, Husa P, Kerkovský M
Klinika infekcních chorob Lékarské fakulty Masarykovy univerzity a Fakultní nemocnice Brno.
Klin Mikrobiol Infekc Lek. 2008 Aug;14(4):149-53.
Infection caused by the anaerobic gram-negative rod Fusobacterium nucleatum belongs to endogenous infections. A 41-year-old man developed multiple brain abscesses of odontogenic origin. The main causes were poor oral hygiene and no dental check-ups. Pus aspired from a site in the brain contained DNA of the bacterium Fusobacterium nucleatum. Several teeth with periapical abscesses were extracted. Initially, the patient was treated empirically with a combination of cefotaxime and metronidazole (18 days). Subsequently, co-trimoxazole and rifampicin were administered (8 months). Four and eight months after the onset of the disease, MRI scans revealed only persistent residual changes in the brain parenchyma; the patient was asymptomatic, with no neurological signs and back at work.
由厌氧革兰氏阴性杆菌具核梭杆菌引起的感染属于内源性感染。一名41岁男性患上了多起因牙源性引起的脑脓肿。主要原因是口腔卫生差且未进行牙齿检查。从脑部一个部位抽出的脓液中含有具核梭杆菌的DNA。拔除了几颗患有根尖脓肿的牙齿。起初,患者接受了头孢噻肟和甲硝唑联合治疗(18天)。随后,给予复方新诺明和利福平治疗(8个月)。疾病发作后4个月和8个月时,MRI扫描显示脑实质仅存在持续的残留变化;患者无症状,无神经体征,已重返工作岗位。