一名有药物滥用史的年轻男性因具核梭杆菌引起的小脑脓肿导致快速脑死亡：病例报告
Rapid brain death caused by a cerebellar abscess with Fusobacterium nucleatum in a young man with drug abuse: a case report.
作者信息
Hischebeth Gunnar T R, Keil Vera C, Gentil Katrin, Boström Azize, Kuchelmeister Klaus, Bekeredjian-Ding Isabelle
机构信息
Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital Bonn, Sigmund-Freud-Str, 25, D-53127 Bonn, Germany.
出版信息
BMC Res Notes. 2014 Jun 10;7:353. doi: 10.1186/1756-0500-7-353.
BACKGROUND
Fusobacterium nucleatum is a strict anaerobic microorganism that causes disease entities such as periodontal and soft tissue abscesses, pulmonary and intraabdominal infections and very rarely intracerebral infections.
CASE PRESENTATION
Here, we report the rare case of a previously healthy 25-year-old German man with a cerebellar abscess caused by Fusobacterium nucleatum that resulted in rapid brain death. Toxicological screening showed positivity for amphetamines and cannabis. The diagnosis was obtained by polymerase chain reaction amplification of bacterial deoxyribonucleic acid in cerebrospinal fluid.
CONCLUSIONS
In drug users clinicians should think about rare causes of brain abscesses/meningitis. Early diagnosis is necessary and justifies the use of molecular techniques.
背景
具核梭杆菌是一种严格厌氧微生物，可引发牙周和软组织脓肿、肺部和腹腔内感染等疾病，极少引发脑内感染。
病例报告
在此，我们报告一例罕见病例，一名25岁既往健康的德国男子因具核梭杆菌导致小脑脓肿，进而迅速脑死亡。毒理学筛查显示苯丙胺和大麻呈阳性。通过对脑脊液中细菌脱氧核糖核酸进行聚合酶链反应扩增得出诊断结果。
结论
对于吸毒者，临床医生应考虑脑脓肿/脑膜炎的罕见病因。早期诊断很有必要，这也证明了分子技术的应用合理性。
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