甲氨蝶呤暴露的四年经验。
Four-year experience with methotrexate exposures.
作者信息
LoVecchio Frank, Katz Kenneth, Watts David, Wood Ian
机构信息
Banner Good Samaritan Regional Poison Center, Maricopa Medical Center, Department of Emergency Medicine, Phoenix, AZ, USA.
出版信息
J Med Toxicol. 2008 Sep;4(3):149-50. doi: 10.1007/BF03161192.
INTRODUCTION
Unintentional methotrexate (MTX) acute oral overdose is rarely reported.
METHODS
We conducted a retrospective chart review of all human exposure calls (>150,000 charts) for MTX ingestions reported to our Poison Center during 2000-2003.
RESULTS
Thirteen patients met the criteria. The average amount of MTX ingested was 13.03 mg (data from 7 cases), and the average patient age was 43 years (20 months to 80 years). No significant toxicities occurred.
DISCUSSION
Although intravenous MTX toxicity can be severe, this does not appear to be a phenomenon associated with either acute unintentional or suicidal oral ingestion.
引言
甲氨蝶呤（MTX）急性经口意外过量摄入的报道很少。
方法
我们对2000年至2003年期间向我们毒物中心报告的所有MTX摄入人体暴露电话记录（超过150,000份记录）进行了回顾性图表审查。
结果
13名患者符合标准。MTX的平均摄入量为13.03毫克（7例数据），患者平均年龄为43岁（20个月至80岁）。未发生明显毒性反应。
讨论
尽管静脉注射MTX毒性可能很严重，但这似乎不是急性意外或自杀性经口摄入所伴随的现象。
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