Monfils Gustafsson W, Josefsson A, Ekholm Selling K, Sydsjö G
Division of Obstetrics and Gynaecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Acta Psychiatr Scand. 2009 Jan;119(1):54-61. doi: 10.1111/j.1600-0447.2008.01267.x. Epub 2008 Sep 19.
Preterm birth and restricted foetal growth are related to symptoms of psychiatric disorder. Our aim was therefore to investigate possible relations between being born preterm and/or small for gestational age (SGA) and later psychiatric hospitalization.
A population-based registry study of psychiatric hospitalization of in total 155,994 boys and 148,281 girls born in Sweden in 1973-1975.
The risk of hospitalization for all mental disorders was increased for preterm SGA boys (OR 2.19, 95% CI 1.49-3.21); at-term SGA boys (OR 1.55, 95% CI 1.34-1.79); at-term SGA girls (OR 1.31, 95% CI 1.15-1.50). At-term SGA boys and girls suffered increased risk of anxiety and adjustment disorders (OR 1.70, 95% CI 1.18-2.45 and OR 1.49, 95% CI 1.14-1.94). Preterm SGA boys were at risk of personality disorders (OR 3.30, 95% CI 1.16-9.41) and psychotic disorders (OR 4.36, 95% CI 1.85-10.30).
The results show a relationship between being born SGA and later psychiatric hospitalization, where preterm birth and male gender seem to increase the risk.
早产和胎儿生长受限与精神障碍症状有关。因此，我们的目的是调查早产和/或小于胎龄儿（SGA）与后期精神科住院治疗之间可能存在的关系。
一项基于人群的登记研究，对象为1973 - 1975年在瑞典出生的155,994名男孩和148,281名女孩的精神科住院情况。
早产SGA男孩患所有精神障碍的住院风险增加（比值比2.19，95%置信区间1.49 - 3.21）；足月SGA男孩（比值比1.55，95%置信区间1.34 - 1.79）；足月SGA女孩（比值比1.31，95%置信区间1.15 - 1.50）。足月SGA男孩和女孩患焦虑和适应障碍的风险增加（比值比1.70，95%置信区间1.18 - 2.45和比值比1.49，95%置信区间1.14 - 1.94）。早产SGA男孩有患人格障碍（比值比3.30，95%置信区间1.16 - 9.41）和精神障碍（比值比4.36，95%置信区间1.85 - 10.30）的风险。
结果显示小于胎龄儿出生与后期精神科住院治疗之间存在关联，早产和男性性别似乎会增加这种风险。
