臭氧化腐殖质成分的致突变性。

Mutagenicity of the components of ozonated humic substance.

作者信息

Matsuda H, Ose Y, Nagase H, Sato T, Kito H, Sumida K

机构信息

Mie University Hospital, Tsu City, Japan.

出版信息

Sci Total Environ. 1991 Apr 15;103(2-3):129-40. doi: 10.1016/0048-9697(91)90139-6.

DOI:10.1016/0048-9697(91)90139-6

PMID:1882229

Abstract

Eight components of humic substances were ozonated. Mutagenic activity was found with TA100 with and without S9 mix for all ozonated components. Ozonated products of p-hydroxybenzaldehyde were separated into five fractions by silica gel chromatography and each fraction subjected to mutagenicity assay. Mutagenic activity was found in the chloroform and chloroform-acetone (1:1) fractions. The compounds in these fractions were identified, and aldehydes such as formaldehyde, acetaldehyde, glyoxal, glyoxylic acid and methyl glyoxal were found to be mutagenic. Mutagenic compounds are present in the polar fraction.

摘要

对腐殖质的八个组分进行了臭氧处理。在有和没有S9混合物的情况下，TA100对所有经臭氧处理的组分均表现出诱变活性。对羟基苯甲醛的臭氧处理产物通过硅胶柱色谱法分离成五个馏分，并对每个馏分进行致突变性测定。在氯仿和氯仿 - 丙酮（1:1）馏分中发现了诱变活性。鉴定了这些馏分中的化合物，发现甲醛、乙醛、乙二醛、乙醛酸和甲基乙二醛等醛类具有诱变作用。诱变化合物存在于极性馏分中。