长QT综合征中的T（峰）-T（终）间期
T(peak)T(end) interval in long QT syndrome.
作者信息
Kanters Jorgen K, Haarmark Christian, Vedel-Larsen Esben, Andersen Mads P, Graff Claus, Struijk Johannes J, Thomsen Poul Erik Bloch, Christiansen Michael, Jensen Henrik K, Toft Egon
机构信息
Danish National Research Foundation Center of Arrhythmias (DARC), Copenhagen, Denmark.
出版信息
J Electrocardiol. 2008 Nov-Dec;41(6):603-8. doi: 10.1016/j.jelectrocard.2008.07.024. Epub 2008 Sep 25.
BACKGROUND
The T(peak)T(end) (T(p)T(e)) interval is believed to reflect the transmural dispersion of repolarization. Accordingly, it should be a risk factor in long QT syndrome (LQTS). The aim of the study was to determine the effect of genotype on T(p)T(e) interval and test whether it was related to the occurrence of syncope.
METHODS
Electrocardiograms were taken in 95 patients with LQTS drawn from the Danish long QT registry (44 patients with KvLQT1, 43 with HERG, and 8 with SCN5A mutations) and manually evaluated for the QT, QT(peak), and RR interval.
RESULTS AND CONCLUSION
(1) T(p)T(e) cannot be used to distinguish symptomatic from asymptomatic patients with LQTS; (2) HERG patients have longer T(p)T(e) than KvLQT1 patients; and (3) there is no need to heart rate-correct T(p)T(e) intervals in patients with LQTS.
背景
T（峰）T（末）（T(p)T(e)）间期被认为可反映复极的跨壁离散度。因此，它应是长QT综合征（LQTS）的一个危险因素。本研究的目的是确定基因型对T(p)T(e)间期的影响，并检验其是否与晕厥的发生有关。
方法
从丹麦长QT注册中心选取95例LQTS患者进行心电图检查（44例KvLQT1突变患者、43例HERG突变患者和8例SCN5A突变患者），并人工评估QT、QT(峰)和RR间期。
结果与结论
（1）T(p)T(e)不能用于区分有症状和无症状的LQTS患者；（2）HERG突变患者的T(p)T(e)比KvLQT1突变患者长；（3）LQTS患者无需对T(p)T(e)间期进行心率校正。
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