Kanters Jørgen K, Graff Claus, Andersen Mads P, Hardahl Thomas, Toft Egon, Christiansen Michael, Bloch Thomsen Poul Erik, Struijk Johannes J
Laboratory of Experimental Cardiology, Department of Medical Physiology, University of Copenhagen, DK2200 Copenhagen N, Denmark.
J Electrocardiol. 2006 Oct;39(4 Suppl):S119-22. doi: 10.1016/j.jelectrocard.2006.06.008. Epub 2006 Aug 21.
Diagnosis of long QT syndrome (LQTS) is difficult. A prolonged QT interval is easily overlooked, and in 10% of all patients with LQTS, the QT interval is normal. Genotyping is unfortunately not able to detect all patients and healthy subjects correctly. Although QT prolongation is the most used risk parameter, there is no clear correlation between the prolonged QT interval and the risk of arrhythmias in drug-induced LQTS. Quantification of T-wave morphology is a promising method that is able to provide more information about repolarization than QT prolongation alone. It is a fact that ECG evaluation can serve as a guide for genotyping and can reduce the costs by suggesting which gene to start sequencing, but it is fiction that the ECG can replace genotyping.
长QT综合征（LQTS）的诊断颇具难度。QT间期延长很容易被忽视，在所有LQTS患者中，有10%的患者QT间期是正常的。遗憾的是，基因分型无法正确检测出所有患者和健康受试者。尽管QT延长是最常用的风险参数，但在药物诱发的LQTS中，QT间期延长与心律失常风险之间并无明确关联。T波形态量化是一种很有前景的方法，它能够比单纯的QT延长提供更多关于复极化的信息。事实上，心电图评估可为基因分型提供指导，并通过建议从哪个基因开始测序来降低成本，但认为心电图可以取代基因分型则是不切实际的。
