重组人活化蛋白C对凝血系统的影响：旋转血栓弹力图研究
Effects of recombinant human activated protein C on the coagulation system: a study with rotational thromboelastometry.
作者信息
Nilsson C U, Hellkvist P D, Engström M
机构信息
Lund University Medical School, Lund University, Lund, Sweden.
出版信息
Acta Anaesthesiol Scand. 2008 Oct;52(9):1246-9. doi: 10.1111/j.1399-6576.2008.01735.x.
BACKGROUND
Recombinant human activated protein C (rhAPC) is an anticoagulant that can be used for treatment of patients with severe sepsis. The use of rhAPC is accompanied by an increased risk of severe bleeding. Rotational thromboelastometry is a method for measuring the status of the coagulation. The aim of the study was to investigate whether rotational thromboelastometry could be used for monitoring the effects of rhAPC on the coagulation.
METHODS
Whole blood was mixed in vitro with concentrations of rhAPC ranging from 0 to 75 ng/ml and analysed with rotational thromboelastometry.
RESULTS
The parameter Coagulation Time was significantly prolonged by increasing the concentrations of rhAPC (P=0.002). Other parameters were not significantly affected.
CONCLUSION
rhAPC dose dependently affects the early humoral parts of the coagulation, while platelet function and fibrinogen to fibrin conversion seem virtually unaffected.
背景
重组人活化蛋白C（rhAPC）是一种抗凝剂，可用于治疗严重脓毒症患者。使用rhAPC会增加严重出血的风险。旋转血栓弹力图是一种测量凝血状态的方法。本研究的目的是调查旋转血栓弹力图是否可用于监测rhAPC对凝血的影响。
方法
将全血在体外与浓度范围为0至75 ng/ml的rhAPC混合，并用旋转血栓弹力图进行分析。
结果
随着rhAPC浓度的增加，凝血时间参数显著延长（P = 0.002）。其他参数未受到显著影响。
结论
rhAPC剂量依赖性地影响凝血的早期体液部分，而血小板功能和纤维蛋白原向纤维蛋白的转化似乎几乎未受影响。
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