Bethke Lara, Sullivan Kate, Webb Emily, Murray Anne, Schoemaker Minouk, Auvinen Anssi, Kiuru Anne, Salminen Tiina, Johansen Christoffer, Christensen Helle Collatz, Muir Kenneth, McKinney Patricia, Hepworth Sarah, Dimitropoulou Polyxeni, Lophatananon Artitaya, Feychting Maria, Lönn Stefan, Ahlbom Anders, Malmer Beatrice, Henriksson Roger, Swerdlow Anthony, Houlston Richard
Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Cancer Lett. 2009 Jan 18;273(2):312-5. doi: 10.1016/j.canlet.2008.08.010. Epub 2008 Sep 26.
Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR=1.16; 95% CI: 0.87-1.53; P=0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.
半胱天冬酶8（CASP8）是细胞凋亡或程序性细胞死亡的关键调节因子，因此是对抗癌症的一种防御机制。最近研究表明，CASP8基因多态性D302H会影响患乳腺癌的风险。我们通过分析五个独立的病例组和对照组系列（分别为n = 631和637），来检验CASP8基因多态性D302H可能影响脑膜瘤风险这一假设。302H的携带状态与统计学上显著增加的风险无关（比值比= 1.16；95%置信区间：0.87 - 1.53；P = 0.31），这使得该变体不太可能导致脑膜瘤的遗传风险。
