Dusser Daniel
Faculté Cochin Port-Royal, Service de Pneumologie, Groupe Hospitalier Cochin Saint-Vincent-de-Paul, APHP, Université Paris Descartes, Paris Cedex 14, France.
Presse Med. 2008 Nov;37(11):1599-603. doi: 10.1016/j.lpm.2008.08.004. Epub 2008 Sep 26.
Exacerbations can occur at each stage of chronic obstructive pulmonary disease (COPD), but their frequency and severity increase with disease progression. Today exacerbations are known to have severe immediate and delayed consequences. They aggravate symptoms (dyspnea, cough, and sputum), airflow, and FEV1 decline and impair quality of life--all durably, with prolonged recovery time. They increase the risk of death. Their economic consequences are substantial, accounting for 60% of direct cost associated with COPD - 3 and 9 billion euros per year. Prevention of exacerbations is a major public health objective and is an integral part of the COPD program defined by French health authorities for the 2005-2010 period. It is essential to improve quality of life and prevent worsening of the long-term course of COPD.
慢性阻塞性肺疾病（COPD）的每个阶段都可能发生急性加重，但随着疾病进展，其发作频率和严重程度会增加。如今已知急性加重会产生严重的即时和延迟后果。它们会加重症状（呼吸困难、咳嗽和咳痰）、气流受限以及第一秒用力呼气容积（FEV1）下降，并损害生活质量——所有这些影响都是持久的，恢复时间延长。它们还会增加死亡风险。其经济后果相当严重，占与COPD相关直接成本的60%——每年达30亿至90亿欧元。预防急性加重是一项主要的公共卫生目标，也是法国卫生当局在2005 - 2010年期间确定的COPD项目的一个组成部分。改善生活质量并防止COPD长期病程恶化至关重要。
