Kolebinov N, Elazarova F, Stoilova I, Milanov S, Popov P
Vutr Boles. 1976;15(4):62-8.
The total non-conjugated plasma cortisol in 60 patients with hypertension disease (HD)is 17.5 mkg/ml. The free non-conjugated cortisol represents 8.45 per cent of the total - 1,5 mkg%, considerably (p less than 0.0001) higher than that in healthy subjects. Protein conjugated cortisol is 16.0 mkg%. The bounding capacity of transcortin the plasma of hypertonics is considerably decreased (p less than 0.0001) - 15.8 mkg (in healthy - 18.5 mkg) per 100 ml. ACTH level in the plasma of patients with HD is 32.0 pg/ml, considerably higher than that in healthy (25.8 pg/ml, p less than 0.0001). The elevation of the biologically active cortisol fraction in plasma of hypertonics is a function both of hypothalamo-hypopheseal stimulation and of transcortin level. That latent hypercortisolism is admitted to be manifestation of hypothalamo - hypopheseal superstimulation by increased ACTH secretion, in case of confirmed cerebro-hypothalamic disturbances in patients with hypertension disease.
60例高血压病患者血浆中总非结合皮质醇为17.5微克/毫升。游离非结合皮质醇占总量的8.45%，即1.5微克%，显著高于健康受试者（p<0.0001）。蛋白结合皮质醇为16.0微克%。高血压患者血浆中皮质素转运蛋白的结合能力显著降低（p<0.0001），每100毫升为15.8微克（健康人为18.5微克）。高血压病患者血浆中促肾上腺皮质激素（ACTH）水平为32.0皮克/毫升，显著高于健康人（25.8皮克/毫升，p<0.0001）。高血压患者血浆中生物活性皮质醇部分的升高是下丘脑-垂体刺激和皮质素转运蛋白水平共同作用的结果。如果高血压病患者经证实存在脑-下丘脑功能紊乱，那么潜在的皮质醇增多症被认为是由于ACTH分泌增加导致下丘脑-垂体过度刺激的表现。
