Wilson Debra Rose, Warise Lita
School of Nursing, Middle Tennessee State University, Murfreesboro, TN, USA.
Perspect Psychiatr Care. 2008 Oct;44(4):285-9. doi: 10.1111/j.1744-6163.2008.00188.x.
This study aims to review the cytokines that mediate the inflammatory process, the interleukins and the interferons, and the interaction of cytokines with serotonin as causative factors in the role of depression.
Administration of proinflammatory cytokines to treat medical diseases induces depressive symptoms in humans. Patients diagnosed with depression tend to have high levels of cytokine activity and impaired immune response, as well as those patients suffering from inflammatory processes. Proinflammatory cytokines interfere with the body's feedback loop to reduce circulating corticosteroids during the stress response.
Serotonin levels, integrally associated with depression, are lowered when levels of circulating cytokines are high when the precursor tryptophan is reduced.
本研究旨在综述介导炎症过程的细胞因子、白细胞介素和干扰素，以及细胞因子与血清素之间的相互作用，它们作为抑郁症发病的致病因素。
给予促炎细胞因子治疗医学疾病会在人类中诱发抑郁症状。被诊断为抑郁症的患者往往具有高水平的细胞因子活性和受损的免疫反应，患有炎症性疾病的患者也是如此。促炎细胞因子会干扰身体的反馈回路，以减少应激反应期间循环皮质类固醇的水平。
当循环细胞因子水平较高且前体色氨酸减少时，与抑郁症密切相关的血清素水平会降低。
