Kumar Sangit, Johansson Henrik, Kanda Takahiro, Engman Lars, Müller Thomas, Jonsson Mats, Pedulli Gian Franco, Petrucci Silvia, Valgimigli Luca
Department of Biochemistry and Organic Chemistry, Uppsala University, Box 576, SE-75123 Uppsala, Sweden.
Org Lett. 2008 Nov 6;10(21):4895-8. doi: 10.1021/ol801983n. Epub 2008 Oct 2.
When assayed for their capacity to inhibit azo-initiated peroxidation of linoleic acid in a water/chlorobenzene two-phase system, tellurium-containing 3-pyridinols were readily regenerable by N-acetylcysteine contained in the aqueous phase. The best inhibitors quenched peroxyl radicals more efficiently than alpha-tocopherol, and the duration of inhibition was limited only by the availability of the thiol reducing agent. The compounds were also found to catalyze reduction of hydrogen peroxide in the presence of thiol reducing agent.
当在水/氯苯两相体系中测定含碲3-吡啶醇抑制偶氮引发的亚油酸过氧化的能力时，水相中的N-乙酰半胱氨酸可使含碲3-吡啶醇易于再生。最佳抑制剂淬灭过氧自由基的效率高于α-生育酚，抑制持续时间仅受硫醇还原剂可用性的限制。还发现这些化合物在硫醇还原剂存在下可催化过氧化氢的还原。
