Weinstein R A
Michael Reese Hospital and Medical Center, Chicago, Illinois 60616.
Am J Med. 1991 Aug 8;91(2A):132S-134S. doi: 10.1016/0002-9343(91)90465-a.
Conventional infection control measures in intensive care units (ICUs) are aimed primarily at stemming cross-infections. The role of patients' endogenous flora in the pathogenesis of nosocomial infection and occasional lapses in aseptic technique in ICUs help to explain the frequent failure of the conventional approaches. Newer control strategies include avoiding gastric and oropharyngeal overgrowth of gram-negative bacilli by using sucralfate to avoid gastric alkalinization and/or suppressing nosocomial flora by use of topical antimicrobials.
重症监护病房（ICU）的传统感染控制措施主要旨在阻止交叉感染。患者内源性菌群在医院感染发病机制中的作用以及ICU中无菌技术偶尔出现的失误，有助于解释传统方法为何常常失败。新的控制策略包括使用硫糖铝避免胃碱化，以防止革兰氏阴性杆菌在胃和口咽部过度生长，和/或使用局部抗菌药物抑制医院内菌群。
