绵羊孕期及分娩期母羊血浆和羊水内卵泡抑素浓度的变化

Changes in concentrations of follistatin in maternal plasma and foetal fluids during pregnancy and parturition in sheep.

作者信息

Xia Yin, O'Shea Tim, McFarlane James R

机构信息

Centre for Bioactive Discovery in Health and Aging, University of New England, Armidale NSW 2351, Australia.

出版信息

Anim Reprod Sci. 2009 Aug;114(1-3):148-56. doi: 10.1016/j.anireprosci.2008.08.022. Epub 2008 Aug 28.

DOI:10.1016/j.anireprosci.2008.08.022

PMID:18829189

Abstract

Studies have shown that follistatin may be involved in the regulation of ovarian development, pregnancy and parturition. The aim of the present study was to measure follistatin levels in maternal plasma and foetal fluids during pregnancy and parturition in sheep. Using a previously described follistatin radioimmunoassay, we found that follistatin in foetal plasma and allantoic fluid was higher in the female than in the male at days 50-75 of gestation. Follistatin concentrations in maternal plasma declined from -9 to -3h before the completion of lamb delivery, and increased from 21 to 39 h after parturition. These results suggest that follistatin may play a role in femaleness development, and that follistatin may be involved in the mechanism of normal parturition and in regulation of the tissue repair after parturition.

摘要

研究表明，卵泡抑素可能参与卵巢发育、妊娠和分娩的调节。本研究的目的是测定绵羊妊娠和分娩期间母羊血浆和胎儿体液中的卵泡抑素水平。使用先前描述的卵泡抑素放射免疫分析法，我们发现，在妊娠第50 - 75天，雌性胎儿血浆和尿囊液中的卵泡抑素高于雄性。母羊血浆中卵泡抑素浓度在羔羊分娩结束前从-9小时降至-3小时，并在分娩后21至39小时升高。这些结果表明，卵泡抑素可能在雌性发育中起作用，并且可能参与正常分娩机制以及分娩后组织修复的调节。