Colletti V, Fiorino F G
ENT Department, University of Verona, Ospedale Borgo Roma, Verona, Italy.
Am J Otol. 1991 May;12(3):195-8.
The present investigation evaluates the effectiveness of NaF treatment in modifying the natural course of subclinical otosclerosis, as monitored by the stapedius reflex. The study was carried out on 128 relatives of patients suffering from surgically confirmed footplate otosclerosis. The diagnosis of subclinical otosclerosis was made on the basis of presence of the on-off effect. One group of subjects was treated with NaF in doses ranging from 6 to 16 mg according to age. The treatment lasted 2 years. A second group served as a control. Changes in stapedius reflex morphology were evaluated at 1, 2, and 5 years from the onset of treatment. The investigation demonstrated that NaF has a stabilizing effect on early otosclerosis. This drug, in fact, arrests the disease process in more than 60 percent of ears at the 2-year follow-up and in more than 50 percent at 5 years. A program of secondary prevention of otosclerosis by NaF is suggested.
本研究通过镫骨肌反射监测，评估氟化钠（NaF）治疗对亚临床耳硬化自然病程的改善效果。该研究针对128例经手术确诊为镫骨底板耳硬化患者的亲属展开。亚临床耳硬化的诊断基于开关效应的存在。一组受试者根据年龄接受6至16毫克剂量的NaF治疗。治疗持续2年。另一组作为对照。在治疗开始后的1年、2年和5年评估镫骨肌反射形态的变化。研究表明，NaF对早期耳硬化有稳定作用。事实上，在2年随访时，该药使超过60%的耳朵病情得到控制，5年时超过50%。建议开展NaF预防耳硬化的二级预防项目。
