Hilliker Angela, Parker Roy
Department of Molecular and Cellular Biology and Howard Hughes Medical Institute, University of Arizona, Tucson, AZ 85721-0106, USA.
Nat Cell Biol. 2008 Oct;10(10):1129-30. doi: 10.1038/ncb1008-1129.
Stress granules and processing bodies are related mRNA-containing granules implicated in controlling mRNA translation and decay. A genomic screen identifies numerous factors affecting granule formation, including proteins involved in -GlcNAc modifications. These results highlight the importance of post-translational modifications in translational control and mRNP granule formation.
应激颗粒和加工小体是与控制mRNA翻译和降解相关的含mRNA颗粒。一项基因组筛选鉴定出许多影响颗粒形成的因子,包括参与N-乙酰葡糖胺修饰的蛋白质。这些结果突出了翻译后修饰在翻译控制和mRNA核糖核蛋白颗粒形成中的重要性。