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[远志蔗糖酯抗抑郁成分的研究]

[Study on antidepressant components of sucrose ester from Polygala tenuifolia].

作者信息

Tu Hai-Hua, Liu Ping, Mu Liang, Liao Hong-Bo, Xie Ting-Ting, Ma Li-Hua, Liu Yao-Ming

机构信息

Dept of Clinical Pharmacology, General Hospital of PIM, Beijing 100853, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2008 Jun;33(11):1278-80.

PMID:18831206

Abstract

OBJECTIVE

To investigate the antidepressant components of Polygala tenuifolia.

METHOD

The chromatographic method was used to isolate and purify the chemical constituents, their structures were identified by spectral analysis, MTT method was applied to investigate their cytotoxic activities.

RESULT

Nine compounds were isolated from the roots of P. tenuifolia. Their structures were identified as sibiricose A, (1), sibiricose A5 (2), tenuifoliside A (3) and 3', 6-disinapoyl sucrose (4), sibiricose A6 (5), 3, 4, 5-trimethoxycinnamate (6), polygalaxanthone III (7), tenuifolioses A (8), tenuifolioses H (9) and some compounds' activities to PC12 were observed.

CONCLUSION

Compound 1 was isolated from this plant for the first time. Compounds 2,3 could protect PC12 cells damage induced by P. tenuifolia.

摘要

目的

研究远志的抗抑郁成分。

方法

采用色谱法分离纯化化学成分，通过光谱分析鉴定其结构，运用MTT法研究其细胞毒性活性。

结果

从远志根中分离出9种化合物。其结构鉴定为西伯利亚远志糖A，（1），西伯利亚远志糖A5（2），细叶远志皂苷A（3）和3'，6-二芥子酰蔗糖（4），西伯利亚远志糖A6（5），3，4，5-三甲氧基肉桂酸（6），多花远志酮III（7），细叶远志糖A（8），细叶远志糖H（9），并观察到部分化合物对PC12细胞的活性。