Parkhomenko Iu G, Ali-Riza A E, Lozovskaia L S, Grun'ko V A
Arkh Patol. 1991;53(5):33-8.
The characteristics of viral-bacterial lesion in the appendix of children with appendicitis are given by means of histologic, histochemical, immunomorphological and morphometric methods. Antigens of influenza viruses A, B, C, entero-, adeno- and paramyxoviruses were observed among which influenza C was found significantly more frequently (64.1%). Viral infection in the majority of cases (79.5%) was found in the association with opportunistic flora, more frequently with E. coli, and less R. aeruginosa and Klebsiella. Analysis of the immunomorphological shifts in the appendix indicated a peculiar dynamics of the antibody production in acute appendicitis: the enhancement of the IgG, IgD and IgE production and the decrease of the production of IgA and IgM. The viral-bacterial effect, the development of the immune responses with IgE hyperproduction and participation in this process of labrocytes and endocrine cells suggest the integration of the two pathogenetic mechanisms-infectious and allergic.
采用组织学、组织化学、免疫形态学和形态计量学方法，对小儿阑尾炎阑尾的病毒-细菌病变特征进行了研究。观察到甲型、乙型、丙型流感病毒、肠道病毒、腺病毒和副粘病毒的抗原，其中丙型流感病毒的检出频率显著更高（64.1%）。在大多数病例（79.5%）中，病毒感染与机会性菌群相关，更常见的是与大肠杆菌相关，较少与铜绿假单胞菌和克雷伯菌相关。阑尾免疫形态学变化分析表明，急性阑尾炎中抗体产生具有特殊动态：IgG、IgD和IgE产生增强，而IgA和IgM产生减少。病毒-细菌效应、伴有IgE过度产生的免疫反应的发展以及淋巴细胞和内分泌细胞参与这一过程，提示了感染性和过敏性这两种发病机制的整合。
