Kofteridis D P, Notas G, Maraki S, Anastasopoulos T, Papazoglou G, Zisiou A T, Mantadakis E, Samonis G
Infectious Diseases Unit, Division of Medicine, University of Crete, Heraklion, Greece.
Chemotherapy. 2008;54(6):492-8. doi: 10.1159/000160183. Epub 2008 Oct 3.
Haemophilus influenzae is an important human pathogen.
The purpose of the present retrospective study is to describe the antibiotic susceptibility to several common antibiotics of 930 consecutive clinical isolates of H. influenzae over the period of 1996-2005 in a tertiary general hospital on the island of Crete, Greece.
Overall, 9.5% of the isolates were beta-lactamase producing. Resistance to ampicillin and amoxicillin-clavulanate was observed in 11 and 0.6% of the strains, respectively, remaining stable throughout the study period. Resistance to tetracycline increased from 1.6% in 1996 to 38% in 2005, while resistance to ciprofloxacin and ofloxacin was <1%. A significant decrease in resistance to trimethoprim-sulfamethoxazole was observed during the study period. No significant changes in resistance to other antimicrobials were seen.
Amoxicillin-clavulanate and older quinolones remain potent agents against H. influenzae. Constant surveillance ofantibiotic susceptibility of H. influenzae clinical isolates is important in order to guide appropriate empirical antibiotic therapy.
流感嗜血杆菌是一种重要的人类病原体。
本回顾性研究的目的是描述1996年至2005年期间希腊克里特岛一家三级综合医院连续分离出的930株流感嗜血杆菌对几种常用抗生素的药敏情况。
总体而言，9.5%的分离株产β-内酰胺酶。分别有11%和0.6%的菌株对氨苄西林和阿莫西林-克拉维酸耐药，在整个研究期间保持稳定。对四环素的耐药率从1996年的1.6%增至2005年的38%，而对环丙沙星和氧氟沙星的耐药率<1%。在研究期间观察到对甲氧苄啶-磺胺甲恶唑的耐药率显著下降。对其他抗菌药物的耐药性未见明显变化。
阿莫西林-克拉维酸和较老的喹诺酮类药物仍然是抗流感嗜血杆菌的有效药物。持续监测流感嗜血杆菌临床分离株的药敏情况对于指导适当的经验性抗生素治疗很重要。
