Naumov George N, Folkman Judah, Straume Oddbjorn, Akslen Lars A
Department of Surgery, Harvard Medical School; and Vascular Biology Program, Children's Hospital Boston, Boston, MA, USA.
APMIS. 2008 Jul-Aug;116(7-8):569-85. doi: 10.1111/j.1600-0463.2008.01213.x.
Tumor progression is dependent on a number of sequential steps, including initial tumor-vascular interactions and recruitment of blood vessels (i.e., the angiogenic switch), as well as tumor cells interacting with the surrounding microenvironment and its different components. Failure of a microscopic tumor to complete one or more of these early stages may lead to delayed clinical manifestation of the cancer and a state of stable non-progressing disease (i.e., tumor dormancy). In this review, some of the clinical and experimental evidence is summarized, suggesting that microscopic human cancers, either primary, recurrent or metastatic, can remain in an asymptomatic, non-detectable, and occult state for a long period of time. We also review current experimental human tumor dormancy models which closely recapitulate clinically observed delay in tumor progress.
肿瘤进展依赖于一系列连续步骤，包括初始肿瘤与血管的相互作用以及血管募集（即血管生成开关），还有肿瘤细胞与周围微环境及其不同成分的相互作用。微小肿瘤未能完成这些早期阶段中的一个或多个阶段，可能导致癌症临床表现延迟以及疾病稳定不进展状态（即肿瘤休眠）。在本综述中，总结了一些临床和实验证据，表明原发性、复发性或转移性人类微小癌症可长时间处于无症状、不可检测的隐匿状态。我们还综述了当前的实验性人类肿瘤休眠模型，这些模型密切重现了临床上观察到的肿瘤进展延迟情况。
