Kuks J B, Oosterhuis H J, Limburg P C, The T H
Department of Neurology, University Hospital Groningen, The Netherlands.
J Autoimmun. 1991 Apr;4(2):197-211. doi: 10.1016/0896-8411(91)90018-8.
Clinical course and changes in serum levels of antibodies to the acetylcholine receptor (a-AChR) were followed in 82 patients with myasthenia gravis during a period of 1-8 years after thymectomy. Decrease in a-AChR immediately after thymectomy was influenced by changes in a total IgG. Immunosuppressive medication affected serum a-AChR at all points of time. In a subgroup of 41 patients without thymoma who had no immunosuppressive drugs, there was a steady decrease in a-AChR concomitant with clinical improvement from 6 weeks after thymectomy.
对82例重症肌无力患者在胸腺切除术后1至8年期间的临床病程及血清抗乙酰胆碱受体抗体（a-AChR）水平变化进行了跟踪。胸腺切除术后a-AChR的立即下降受总IgG变化的影响。免疫抑制药物在所有时间点均影响血清a-AChR。在41例无胸腺瘤且未使用免疫抑制药物的患者亚组中，自胸腺切除术后6周起，a-AChR持续下降，同时临床症状改善。
