Braszko Jan J
Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274 Bialystok, Poland.
Eur Neuropsychopharmacol. 2009 Feb;19(2):85-91. doi: 10.1016/j.euroneuro.2008.08.011. Epub 2008 Oct 5.
In this study effect of L745,870, a selective D(4) dopamine (DA) receptor blocker, on the pro-cognitive action of intracerebroventricularly (icv) injected angiotensin IV (Ang IV) and des-Phe(6)-Ang IV was examined. Male Wistar rats weighing 180-200 g were used. Both peptides given at the dose of 1 nmol facilitated recall of a passive avoidance (PA) behaviour, improved object recognition (OR) memory, decreased number of errors, increased number of sequential correct entries and shortened time-to-goal in an eight-arm radial maze (RM). In the auxiliary tests performed to control for the participation of unspecific motor (open field, OF) and emotional ('plus' maze, PM) effects of our treatment in the results of memory tests they had either no (OF) or negligible (PM) effects. Intraperitoneal pretreatment of the animals with 1 mg/kg of L745,870 abolished effects of both peptides on PA and OR and slightly diminished those observed in the eight-arm RM.
在本研究中，检测了选择性D(4)多巴胺（DA）受体阻滞剂L745,870对脑室内（icv）注射血管紧张素IV（Ang IV）和去苯丙氨酸(6)-血管紧张素IV促认知作用的影响。使用体重为180 - 200 g的雄性Wistar大鼠。两种肽以1 nmol的剂量给药时，可促进被动回避（PA）行为的记忆恢复，改善物体识别（OR）记忆，减少错误数量，增加连续正确进入的数量，并缩短八臂放射状迷宫（RM）中的到达目标时间。在为控制我们的处理对记忆测试结果的非特异性运动（旷场，OF）和情绪（“+”迷宫，PM）影响的参与而进行的辅助测试中，它们要么没有（OF）影响，要么影响可忽略不计（PM）。用1 mg/kg的L745,870对动物进行腹腔预处理，消除了两种肽对PA和OR的影响，并略微减弱了在八臂RM中观察到的影响。
