Recurrent intrahepatic cholestasis of pregnancy. A case report.

Intrahepatic cholestasis of pregnancy (ICP) represents a rare but severe pathology with serious consequences on the outcome of pregnancy. We present the cases of two sisters that came to our clinic with ICP in successive pregnancies. The fetus from a pregnancy with cholestasis can be affected by preterm birth, respiratory distress syndrome, intrauterine death in the third trimester and a possible cerebral damage. Early diagnosis and prednisone treatment have allowed an improvement of the neonatal outcome in the following pregnancies.