高血压与11β-羟类固醇脱氢酶II型的循环mRNA

Hypertension and circulating mRNA for 11beta-hydroxysteroid dehydrogenase type II.

作者信息

Agalou S, Butt A N, Chowienczyk Phil, Swaminathan R

机构信息

Department of Chemical Pathology, Guy's and St. Thomas' Hospital NHS Foundation Trust, London, United Kingdom.

出版信息

Ann N Y Acad Sci. 2008 Aug;1137:290-5. doi: 10.1196/annals.1448.005.

DOI:10.1196/annals.1448.005

PMID:18837962

Abstract

Circulating DNA and mRNA for 11beta-hydoxysteroid dehydrogenase (HSD) type II were measured in patients with hypertension and in healthy subjects. DNA and RNA levels in hypertensive patients and controls were quantified using real-time RT-PCR. Messenger RNA for 11beta-HSD type II was significantly lower in the hypertensive patients (median: 0.18) (P= 0.032) than in healthy subjects (median: 0.42). Plasma DNA was also significantly lower (P= 0.016) in hypertension. It is suggested that measurement of mRNA for 11beta-HSD type II in hypertension may identify subjects who may be salt-sensitive.

摘要

在高血压患者和健康受试者中测量了循环DNA以及11β-羟类固醇脱氢酶（HSD）Ⅱ型的mRNA。使用实时逆转录聚合酶链反应（RT-PCR）对高血压患者和对照组中的DNA和RNA水平进行定量。高血压患者中11β-HSDⅡ型的信使RNA水平（中位数：0.18）（P = 0.032）显著低于健康受试者（中位数：0.42）。高血压患者的血浆DNA水平也显著降低（P = 0.016）。提示在高血压患者中测量11β-HSDⅡ型的mRNA可能有助于识别对盐敏感的个体。