Kim Cheol Hong, Kim Yoon Ha, Kim Jong Woon, Kim Ki Min, Cho Moon Kyoung, Kim Seok Mo, Nam Jong Hee, Song Tae-Bok
Department of Obstetrics and Gynecology, Chonnam National University Medical School, Gwangju, Korea.
J Obstet Gynaecol Res. 2008 Aug;34(4 Pt 2):641-4. doi: 10.1111/j.1447-0756.2008.00899.x.
Hydatidiform mole with a coexistent fetus is rare, but this condition has recently shown an increased incidence because of assisted reproduction technology. Herein, we report on a case of triplet pregnancy with a partial hydatidiform mole coexisting with two fetuses. It was diagnosed by p57(kip2) immunohistochemical staining which is helpful in determining histologically equivocal cases. After termination of pregnancy, the patient was diagnosed with persistent gestational trophoblastic disease. Six courses of methotrexate chemotherapy were performed. Her beta-human chorionic gonadotrophin titers then fell to a normal level.
葡萄胎合并存活胎儿的情况较为罕见，但由于辅助生殖技术的应用，这种情况的发生率近来有所上升。在此，我们报告一例三胎妊娠病例，其中部分性葡萄胎与两个胎儿并存。通过p57(kip2)免疫组化染色得以确诊，该染色有助于诊断组织学上模棱两可的病例。终止妊娠后，患者被诊断为持续性滋养细胞疾病。进行了六个疗程的甲氨蝶呤化疗。之后她的β-人绒毛膜促性腺激素水平降至正常。
