Moschetta Antonio
Clinica Medica Murri, University of Bari & Department of Translational Pharmacology, Consorzio Mario Negri Sud, Via Nazionale 8/A, 66030 Santa Maria Imbaro (CH), Italy.
Cell Metab. 2008 Oct;8(4):276-8. doi: 10.1016/j.cmet.2008.09.009.
Homeostatic regulation of bile acid metabolism and biliary lipid secretion is critical to prevent enterohepatic diseases. Kaestner and coworkers (Bochkis et al., 2008) show that loss of forkhead box transcription factor Foxa2 in the liver leads to hepatic injury due to downregulation in the expression levels of bile acid transporters and detoxification enzymes.
胆汁酸代谢和胆汁脂质分泌的稳态调节对于预防肠肝疾病至关重要。凯斯特纳及其同事（博奇斯等人，2008年）表明，肝脏中叉头框转录因子Foxa2的缺失会导致肝脏损伤，原因是胆汁酸转运蛋白和解毒酶的表达水平下调。
