固定小剂量华法林预防全髋关节置换术的疗效
Efficacy of fixed minidose warfarin prophylaxis in total hip replacement.
作者信息
Fordyce M J, Baker A S, Staddon G E
机构信息
Winford Orthopaedic Hospital, Bristol.
出版信息
BMJ. 1991 Jul 27;303(6796):219-20. doi: 10.1136/bmj.303.6796.219.
Abstract
OBJECTIVE
To determine whether a small fixed perioperative dose of warfarin would prevent deep vein thrombosis after total hip replacement.
DESIGN
Prospective, randomised, double blind placebo controlled trial.
SETTING
Winford Orthopaedic Hospital, Bristol.
SUBJECTS
148 patients having primary total hip replacement.
INTERVENTION
Warfarin 1 mg given daily for one week before and three weeks after surgery.
MAIN OUTCOME MEASURE
Deep vein thrombosis diagnosed by the iodine-125 labelled fibrinogen uptake method.
RESULTS
Deep vein thrombosis occurred in 25 (34%) of the patients given warfarin and 19 (26%) of the controls (difference 8%; 95% confidence interval -6.8% to 22.8%).
CONCLUSION
Fixed minidose warfarin does not prevent deep vein thrombosis after total hip replacement.
摘要
目的
确定围手术期小剂量固定剂量的华法林是否能预防全髋关节置换术后深静脉血栓形成。
设计
前瞻性、随机、双盲、安慰剂对照试验。
地点
布里斯托尔温福德骨科医院。
研究对象
148例行初次全髋关节置换术的患者。
干预措施
术前1周及术后3周每天给予1毫克华法林。
主要观察指标
采用碘-125标记纤维蛋白原摄取法诊断深静脉血栓形成。
结果
服用华法林的患者中有25例（34%）发生深静脉血栓形成，对照组中有19例（26%）发生（差异8%；95%置信区间为-6.8%至22.8%）。
结论
固定小剂量华法林不能预防全髋关节置换术后深静脉血栓形成。
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