皮质5-羟色胺1A受体水平与路易体痴呆和帕金森病痴呆患者的抑郁相关。
Cortical serotonin 1A receptor levels are associated with depression in patients with dementia with Lewy bodies and Parkinson's disease dementia.
作者信息
Sharp Sally I, Ballard Clive G, Ziabreva Iryna, Piggott Margaret A, Perry Robert H, Perry Elaine K, Aarsland Dag, Ehrt Uwe, Larsen Jan P, Francis Paul T
机构信息
King's College London, Wolfson Centre for Age-Related Diseases, London, UK.
出版信息
Dement Geriatr Cogn Disord. 2008;26(4):330-8. doi: 10.1159/000161058. Epub 2008 Oct 8.
BACKGROUND
Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression.
AIM
To examine 5-HT(1A) in DLB and PDD postmortem in relation to depression.
METHODS
[(3)H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT(1A) was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls.
RESULTS
5-HT(1A) density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20.
CONCLUSION
Higher BA36 5-HT(1A) density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT(1A) antagonist adjuvant may improve treatment of depression in dementia.
背景
5-羟色胺1A受体（5-HT(1A)）尚未在路易体痴呆（DLB）或患有抑郁症的帕金森病痴呆（PDD）患者中进行研究。
目的
研究DLB和PDD患者死后大脑中5-HT(1A)与抑郁症的关系。
方法
测定了10例DLB患者、17例PDD患者和9例对照者颞叶皮质（布罗德曼区，BA20和BA36）中[³H]8-羟基-2-二丙基氨基四氢萘与5-HT(1A)的结合情况。
结果
合并有抑郁症的DLB/PDD患者BA36区的5-HT(1A)密度显著升高，但BA20区未发生改变。
结论
PDD和DLB患者BA36区5-HT(1A)密度高于对照组，这取决于患者生前是否经历过抑郁症，而非DLB/PDD诊断。5-HT(1A)拮抗剂辅助治疗可能改善痴呆患者的抑郁症治疗。
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