Sharp Sally I, Ballard Clive G, Ziabreva Iryna, Piggott Margaret A, Perry Robert H, Perry Elaine K, Aarsland Dag, Ehrt Uwe, Larsen Jan P, Francis Paul T
King's College London, Wolfson Centre for Age-Related Diseases, London, UK.
Dement Geriatr Cogn Disord. 2008;26(4):330-8. doi: 10.1159/000161058. Epub 2008 Oct 8.
Serotonin 1A receptors (5-HT(1A)) have not been studied in dementia with Lewy bodies (DLB) or Parkinson's disease dementia (PDD) patients with depression.
To examine 5-HT(1A) in DLB and PDD postmortem in relation to depression.
[(3)H]8-hydroxy-2-dipropylaminotetralin binding to 5-HT(1A) was determined in temporal cortex (Brodmann areas, BA20 and BA36) from 10 DLB patients, 17 PDD patients and 9 controls.
5-HT(1A) density was significantly higher in BA36 in combined DLB/PDD patients with depression, but was unaltered in BA20.
Higher BA36 5-HT(1A) density in PDD and DLB patients than in control is dependent on whether the patient had experienced depression during life, not DLB/PDD diagnosis. A 5-HT(1A) antagonist adjuvant may improve treatment of depression in dementia.
5-羟色胺1A受体（5-HT(1A)）尚未在路易体痴呆（DLB）或患有抑郁症的帕金森病痴呆（PDD）患者中进行研究。
研究DLB和PDD患者死后大脑中5-HT(1A)与抑郁症的关系。
测定了10例DLB患者、17例PDD患者和9例对照者颞叶皮质（布罗德曼区，BA20和BA36）中[³H]8-羟基-2-二丙基氨基四氢萘与5-HT(1A)的结合情况。
合并有抑郁症的DLB/PDD患者BA36区的5-HT(1A)密度显著升高，但BA20区未发生改变。
PDD和DLB患者BA36区5-HT(1A)密度高于对照组，这取决于患者生前是否经历过抑郁症，而非DLB/PDD诊断。5-HT(1A)拮抗剂辅助治疗可能改善痴呆患者的抑郁症治疗。
