Brichacek Matthew, Lee Dongeun, Njardarson Jon T
Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, USA.
Org Lett. 2008 Nov 6;10(21):5023-6. doi: 10.1021/ol802123e. Epub 2008 Oct 9.
This paper details the copper-catalyzed ring expansion of vinyl aziridines to 3-pyrrolines. Broad substrate scope (24 examples) using tosyl- and phthalimide-protected vinyl aziridine substrates is observed. Cu(hfacac)2 was determined to be superior to all other catalysts tested.
本文详细介绍了铜催化乙烯基氮杂环丙烷向3-吡咯啉的扩环反应。观察到使用甲苯磺酰基和邻苯二甲酰亚胺保护的乙烯基氮杂环丙烷底物时具有广泛的底物范围(24个实例)。已确定Cu(hfacac)2优于所有其他测试催化剂。