1,2,3,4-四氢-8-羟基喹啉促进的铜催化氮亲核试剂与芳基溴的偶联反应。

1,2,3,4-Tetrahydro-8-hydroxyquinoline-promoted copper-catalyzed coupling of nitrogen nucleophiles and aryl bromides.

作者信息

Wang Huifeng, Li Yaming, Sun Fangfang, Feng Yang, Jin Kun, Wang Xiuna

机构信息

State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China.

出版信息

J Org Chem. 2008 Nov 7;73(21):8639-42. doi: 10.1021/jo8015488. Epub 2008 Oct 9.

DOI:10.1021/jo8015488

PMID:18842030

Abstract

Based on the dramatic accelerating effect of 2-aminophenol, three ligands derived from 2-aminophenol were developed. Copper-catalyzed coupling reaction of nitrogen-containing nucleophiles with aryl bromides was efficiently carried out under mild conditions using 1,2,3,4-tetrahydro-8-hydroxyquinoline as a novel, simple, and versatile ligand.

摘要

基于2-氨基酚显著的加速作用，开发了三种源自2-氨基酚的配体。以1,2,3,4-四氢-8-羟基喹啉作为一种新型、简单且通用的配体，在温和条件下高效地实现了含氮亲核试剂与芳基溴的铜催化偶联反应。