Joëls M, Bouma G, Hesen W, Zegers Y
Division of Molecular Neurobiology, Institute of Molecular Biology, Utrecht, The Netherlands.
Brain Res. 1991 Jun 7;550(2):347-52. doi: 10.1016/0006-8993(91)91340-7.
Pyramidal neurons in the rat CA1 hippocampal area contain intracellular receptors for the steroid hormone corticosterone, and membrane associated alpha- and beta-adrenergic receptors. We compared the effect of noradrenaline (NA) on the synaptically evoked CA1 field potential in adrenalectomized (ADX) rats, where corticosteroid receptors are not occupied, with sham-operated controls. It appeared that the increase in the amplitude of the field potential induced by 10 microM NA was more pronounced in slices from ADX rats than in sham operated controls. In vitro application of 30 nM corticosterone (20 min) to slices from ADX rats shifted the NA-evoked increases in synaptic efficacy towards the level of the sham operated rats. The incidence of a secondary population spike after application of NA was increased in slices from ADX rats compared to slices from sham controls or ADX rats treated with corticosterone. Occupation of receptors for corticosterone in the hippocampal CA1 area may therefore potentially lead to suppression of excitability.
大鼠CA1海马区的锥体神经元含有甾体激素皮质酮的细胞内受体以及与膜相关的α-和β-肾上腺素能受体。我们比较了去甲肾上腺素（NA）对肾上腺切除（ADX）大鼠（其皮质类固醇受体未被占据）和假手术对照组突触诱发的CA1场电位的影响。结果显示，10微摩尔NA诱导的场电位幅度增加在ADX大鼠的切片中比在假手术对照组中更为明显。在体外将30纳摩尔皮质酮应用于ADX大鼠的切片20分钟后，NA诱发的突触效能增加向假手术大鼠的水平转变。与假手术对照组或用皮质酮处理的ADX大鼠的切片相比，ADX大鼠的切片在应用NA后出现继发性群体峰电位的发生率增加。因此，海马CA1区皮质酮受体的占据可能潜在地导致兴奋性的抑制。
