Kawasaki H, Kuwabara H, Hori H, Higashigawa M, Ohkubo T, Sakurai M
Department of Pediatrics, Mie University School of Medicine, Japan.
Cancer Invest. 1991;9(4):409-13. doi: 10.3109/07357909109084638.
In this study, the relationship between the dCTP/ara-CTP ratio and the cytotoxic effect of cytosine arabinoside (ara-C) was investigated. Intracellular levels of dNTPs and ara-CTP were analyzed by high-performance liquid chromatography. Although doubling time and intracellular dCTP levels were different in each of the cells, there was a consistent relation between the intracellular dCTP/ara-CTP ratio and the cytotoxic concentration of ara-C. These data suggest that the intracellular dCTP/ara-CTP ratio is one of the important factors for considering the cytotoxic action of ara-C.
在本研究中，对dCTP/ara-CTP比率与阿糖胞苷（ara-C）的细胞毒性作用之间的关系进行了研究。通过高效液相色谱法分析了细胞内脱氧核苷酸三磷酸（dNTPs）和阿糖胞苷三磷酸（ara-CTP）的水平。尽管每个细胞中的倍增时间和细胞内dCTP水平有所不同，但细胞内dCTP/ara-CTP比率与ara-C的细胞毒性浓度之间存在一致的关系。这些数据表明，细胞内dCTP/ara-CTP比率是考虑ara-C细胞毒性作用的重要因素之一。
