Sorensen R U, Waller R L, Klinger J D
Department of Pediatrics, Louisiana State University Medical Center, New Orleans 70112.
Clin Rev Allergy. 1991 Spring-Summer;9(1-2):47-74. doi: 10.1007/BF02914534.
Chronic pulmonary infection with P. aeruginosa in CF may result from: 1. An initial failure of clearance mechanisms (increased adherence) leading to the development of a highly compartmentalized inflammatory reaction; 2. Inhibition of clearing mechanisms for bacteria present in the bronchial lumen; and 3. A largely ineffective, and possibly damaging, hyperactivity of inflammatory cells in the lumen and bronchial wall. The special relationship between the CF host and P. aeruginos, always long-term, and frequently subtle in its complexity, needs further understanding in order to develop new strategies for the treatment of chronic lung infections with this organism.
囊性纤维化（CF）患者肺部的铜绿假单胞菌慢性感染可能由以下原因导致：1. 清除机制最初失效（黏附增加），导致高度分隔的炎症反应发展；2. 支气管腔内存在的细菌清除机制受到抑制；3. 管腔和支气管壁内炎症细胞的过度活跃在很大程度上无效，甚至可能具有破坏性。CF宿主与铜绿假单胞菌之间的特殊关系一直是长期的，其复杂性往往很微妙，为了开发针对该病原体慢性肺部感染的新治疗策略，需要进一步了解。
