佛波环酯G - K：来自澳大利亚南部海洋海绵Phorbas sp.的新型细胞毒性二萜类化合物

Phorbasins G-K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

作者信息

Zhang Hua, Major Jodie M, Lewis Richard J, Capon Robert J

机构信息

Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia.

出版信息

Org Biomol Chem. 2008 Oct 21;6(20):3811-5. doi: 10.1039/b808866g. Epub 2008 Aug 28.

DOI:10.1039/b808866g

PMID:18843411

Abstract

Fractionation of a cytotoxic extract obtained from a southern Australian marine sponge, Phorbas sp., yielded the known diterpenes phorbasins B-F () together with five new members of the phorbasin family, phorbasins G-K (). Structures were assigned to the new phorbasins based on detailed spectroscopic analysis. A preliminary structure activity relationship (SAR) evaluation based on the co-metabolites phorbasins B-K () revealed aspects of the phorbasin pharmacophore.

摘要

从澳大利亚南部海洋海绵Phorbas sp.中获得的一种细胞毒性提取物经分级分离，得到了已知的二萜类化合物phorbasins B - F（）以及phorbasin家族的五个新成员phorbasins G - K（）。基于详细的光谱分析确定了新phorbasins的结构。基于共代谢物phorbasins B - K（）进行的初步构效关系（SAR）评估揭示了phorbasin药效团的一些方面。