从海绵中分离得到的二萜羧酸——佛波新H的首次合成及绝对构型

First synthesis and absolute configuration of phorbasin H, a diterpene carboxylic acid isolated from the sponge .

作者信息

Takahashi Kensuke, Ogura Yusuke, Kuse Masaki, Takikawa Hirosato

机构信息

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.

Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Japan.

出版信息

Biosci Biotechnol Biochem. 2019 Dec;83(12):2198-2201. doi: 10.1080/09168451.2019.1654850. Epub 2019 Aug 20.

DOI:10.1080/09168451.2019.1654850

PMID:31429643

Abstract

The first synthesis of phorbasin H, a diterpene carboxylic acid isolated from the sponge , was achieved using 1,4--cyclohexanedimethanol and ()-citronellal as starting materials. The data collected in this synthesis indicated the absolute configuration of the naturally occurring phorbasin H to be .

摘要

从海绵中分离得到的二萜羧酸佛巴辛H的首次合成是使用1,4-环己烷二甲醇和（）-香茅醛作为起始原料实现的。该合成过程中收集的数据表明天然存在的佛巴辛H的绝对构型为。