氟代脱氧葡萄糖正电子发射断层扫描（FDG-PET）在复发性结直肠癌中的诊断价值：一项荟萃分析。

Diagnostic value of FDG-PET in recurrent colorectal carcinoma: a meta-analysis.

作者信息

Zhang Chenpeng, Chen Yumei, Xue Huiping, Zheng Ping, Tong Jinlu, Liu Jianjun, Sun Xiaoguang, Huang Gang

机构信息

Department of Nuclear Medicine, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.

出版信息

Int J Cancer. 2009 Jan 1;124(1):167-73. doi: 10.1002/ijc.23926.

DOI:10.1002/ijc.23926

PMID:18844237

Abstract

Accurate detection of recurrent colorectal carcinoma remains a diagnostic challenge. The purposes of this study were to evaluate the diagnostic value of Positron emission tomography (PET) using fluor-18-deoxyglucose (FDG) in recurrent colorectal carcinoma with a meta-analysis. All the published studies in English relating the diagnostic value of FDG-PET in the detection of recurrent colorectal carcinoma were collected. Methodological quality of the included studies was evaluated. Pooled sensitivity, specificity and diagnostic odds ratio and SROC (summary receiver operating characteristic curves) were obtained by the statistical software. Twenty-seven studies were included in the meta-analysis. The pooled sensitivity and specificity for FDG-PET detecting distant metastasis or whole body involvement in recurrent colorectal carcinoma were 0.91 (95% CI 0.88-0.92) and 0.83 (95% CI 0.79-0.87), respectively. The pooled sensitivity and specificity for FDG-PET detecting hepatic metastasis were 0.97 (95% CI 0.95-0.98) and 0.98 (95% CI 0.97-0.99). The pooled sensitivity and specificity for pelvic metastasis or local regional recurrence were 0.94 (95% CI 0.91-0.97) and 0.94 (95% CI 0.92-0.96). FDG-PET is valuable for the assessment of recurrent colorectal carcinoma.

摘要

准确检测复发性结直肠癌仍然是一项诊断挑战。本研究的目的是通过荟萃分析评估使用氟 - 18 - 脱氧葡萄糖（FDG）的正电子发射断层扫描（PET）在复发性结直肠癌中的诊断价值。收集了所有已发表的关于FDG - PET在检测复发性结直肠癌中诊断价值的英文研究。评估纳入研究的方法学质量。通过统计软件获得合并敏感度、特异度、诊断比值比和SROC（汇总受试者工作特征曲线）。荟萃分析纳入了27项研究。FDG - PET检测复发性结直肠癌远处转移或全身受累的合并敏感度和特异度分别为0.91（95%CI 0.88 - 0.92）和0.83（95%CI 0.79 - 0.87）。FDG - PET检测肝转移的合并敏感度和特异度分别为0.97（95%CI 0.95 - 0.98）和0.98（95%CI 0.97 - 0.99）。FDG - PET检测盆腔转移或局部区域复发的合并敏感度和特异度分别为0.94（95%CI 0.91 - 0.97）和0.94（95%CI 0.92 - 0.96）。FDG - PET对复发性结直肠癌的评估具有重要价值。