Zervos Marcus
Division of Infectious Diseases, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Surg Infect (Larchmt). 2008;9 Suppl 1:s29-34. doi: 10.1089/sur.2008.065.supp.
In the United States, methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of skin and soft tissue infections (SSTIs), and toxin-producing community-acquired MRSA (CA-MRSA) strains are becoming the leading cause of SSTIs presenting to emergency departments and outpatient settings. Many of these infections can be treated with oral antibiotics. This review is intended to delineate the types of SSTIs that require antibiotic treatment and to explain which CA-MRSA SSTIs can be treated with oral antibacterial agents.
Review of the literature related to the treatment of CA-MRSA SSTIs with oral antibacterial agents.
Oral antimicrobial agents are available for the treatment of MRSA infection, and most SSTIs caused by CA-MRSA can be treated with these oral agents in an outpatient setting. Variable susceptibilities have been observed for CA-MRSA vs. hospital-acquired MRSA, pointing up the need for clinicians to be vigilant in determining susceptibility patterns.
The growing prevalence of CA-MRSA in SSTIs and the increasing number of these infections observed in both the community and the hospital setting indicates that early, appropriate recognition and treatment are necessary. Many oral antimicrobial agents are available for the treatment of these infections.
在美国，耐甲氧西林金黄色葡萄球菌（MRSA）是皮肤和软组织感染（SSTIs）的主要病因，产毒素的社区获得性MRSA（CA-MRSA）菌株正成为急诊科和门诊就诊的SSTIs的主要病因。这些感染中的许多都可用口服抗生素治疗。本综述旨在描述需要抗生素治疗的SSTIs类型，并解释哪些CA-MRSA SSTIs可用口服抗菌药物治疗。
回顾与口服抗菌药物治疗CA-MRSA SSTIs相关的文献。
有口服抗菌药物可用于治疗MRSA感染，大多数由CA-MRSA引起的SSTIs可在门诊用这些口服药物治疗。已观察到CA-MRSA与医院获得性MRSA的药敏情况有所不同，这表明临床医生在确定药敏模式时需要保持警惕。
CA-MRSA在SSTIs中的患病率不断上升，且在社区和医院环境中观察到的此类感染数量不断增加，这表明早期、恰当的识别和治疗是必要的。有许多口服抗菌药物可用于治疗这些感染。
