Zhang Junling, Adam David N, Stebbing Elaine, Gerbrandt Judith, Lui Harvey, Shapiro Jerry, Zhou Youwen
Psoriasis and Phototherapy Clinic, Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC.
J Cutan Med Surg. 2008 Sep-Oct;12(5):211-6. doi: 10.2310/7750.2008.07069.
Few data exist documenting the effectiveness of psoriasis day-care treatment programs (PDTPs) using standardized efficacy measurements.
We sought to analyze the efficacy of a PDTP using the Psoriasis Area and Severity Index (PASI).
A retrospective review was performed on 132 patients treated at our PDTP. Sufficient data existed to permit PASI analysis using a simplified method for a representative subgroup of 64 patients, who formed the study population. Patients received phototherapy and topical treatments over 2 weeks. The outcome measures included a baseline and day 11 PASI, a physician global assessment (PGA), and adverse events reported by the patients.
Mean baseline PASI was 13.6 (N = 64), with a 59.6% reduction by day 11. A PASI reduction of > or = 50% was seen in 75% of patients, with 30% of patients achieving > or = 75% reduction of PASI. Day 11 PGA demonstrated a 69.9% improvement.
With a reduction in PASI of 59.6% at 11 days, our PDTP, with phototherapy and topical agents, seems to be a rapid and effective therapy for psoriasis.
使用标准化疗效测量方法记录银屑病日间护理治疗项目（PDTPs）有效性的数据很少。
我们试图使用银屑病面积和严重程度指数（PASI）分析一个PDTP的疗效。
对在我们的PDTP接受治疗的132例患者进行回顾性分析。有足够的数据允许对64例患者的代表性亚组使用简化方法进行PASI分析，这些患者构成了研究人群。患者在2周内接受光疗和局部治疗。结局指标包括基线和第11天的PASI、医生整体评估（PGA）以及患者报告的不良事件。
平均基线PASI为13.6（N = 64），到第11天时降低了59.6%。75%的患者PASI降低≥50%，30%的患者PASI降低≥75%。第11天的PGA显示改善了69.9%。
我们的PDTP采用光疗和局部用药，在11天时PASI降低了59.6%，似乎是一种治疗银屑病的快速有效疗法。
